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Site title - Online Inhibitor – papers about Inhibitor

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Brief facts about corticotropin releasing factor:

Corticotropin-releasing hormone is a peptide hormone involved in stress responses. It is a releasing hormone that belongs to corticotropin-releasing factor family. In humans, it is encoded by the CRH gene. Its main function is the stimulation of the pituitary synthesis of adrenocorticotropic hormone, as part of the hypothalamic–pituitary–adrenal axis. Corticotropin-releasing hormone is a 41-amino acid peptide derived from a 196-amino acid preprohormone. CRH is secreted by the paraventricular nucleus of the hypothalamus in response to stress. Increased CRH production has been observed to be associated with Alzheimer's disease and major depression, and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia. In addition to being produced in the hypothalamus, CRH is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta.

Corticotropin-releasing hormone receptor - Corticotropin-releasing hormone receptors, also known as corticotropin-releasing factor receptors are a G protein-coupled receptor family that binds corticotropin-releasing hormone. There are two receptors in the family, designated as type 1 and 2, each encoded by a separate gene.

ACTH - Adrenocorticotropic hormone is a polypeptide tropic hormone produced by and secreted by the anterior pituitary gland. It is also used as a medication and diagnostic agent.

Glucocorticoids - Glucocorticoids are a class of corticosteroids, which are a class of steroid hormones. Glucocorticoids are corticosteroids that bind to the glucocorticoid receptor that is present in almost every vertebrate animal cell.

Proopiomelanocortin - Pro-opiomelanocortin is a precursor polypeptide with 241 amino acid residues. POMC is synthesized in corticotrophs of the anterior pituitary from the 267-amino-acid-long polypeptide precursor pre-pro-opiomelanocortin, by the removal of a 26-amino-acid-long signal peptide sequence during translation.

Hypothalamic-pituitary-adrenal axis - The hypothalamic–pituitary–adrenal axis is a complex set of direct influences and feedback interactions among three components: the hypothalamus, the pituitary gland, and the adrenal glands. These organs and their interactions constitute the HPA axis.

Cushing's syndrome - Cushing's syndrome is a collection of signs and symptoms due to prolonged exposure to glucocorticoids such as cortisol.

Hormones of the hypothalamus-pituitary-adrenal axis

Hormones of the hypothalamus

Peptide hormones